ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells

June 21, 2017

prudect name : ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells
ARN-509

Synonyms: CAS NO: 956104-40-8Molecular Formula: C₂₁H₁₅F₄N₅O₂SMolecular Weight: 477.43Purity: 98% minSolubility: In DMSOStorage: −20°C

574013-66-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18500243