APY0201 is a potent, highly selective PIKfyve kinase inhibitor.APY0201 exerts its inhibitory activity of IL-12/23 production via PIKfyve inhibition. APY0201 inhibited the conversion of PI3P to PI(3,5)P2 in the presence of recombinant human PIKfyve with an IC50 value of 8.9 nM. It is highly selective for PIKfyve compared to various receptors, channels and enzymes including 25 lipid kinases and 83 protein kinases.APY0201 demonstrated potent in vitro inhibitory activity against interleukin(IL)-12p70 production from mouse macrophages and human PBMCs with an IC50 value of 8.4 nM and 9.9 nM, respectively..For the detailed information of APY-0201, the solubility of APY-0201 in water, the solubility of APY-0201 in DMSO, the solubility of APY-0201 in PBS buffer, the animal experiment (test) of APY-0201, the cell expriment (test) of APY-0201, the in vivo, in vitro and clinical trial test of APY-0201, the EC50, IC50,and affinity,of APY-0201

June 21, 2017

prudect name : APY0201 is a potent, highly selective PIKfyve kinase inhibitor.APY0201 exerts its inhibitory activity of IL-12/23 production via PIKfyve inhibition. APY0201 inhibited the conversion of PI3P to PI(3,5)P2 in the presence of recombinant human PIKfyve with an IC50 value of 8.9 nM. It is highly selective for PIKfyve compared to various receptors, channels and enzymes including 25 lipid kinases and 83 protein kinases.APY0201 demonstrated potent in vitro inhibitory activity against interleukin(IL)-12p70 production from mouse macrophages and human PBMCs with an IC50 value of 8.4 nM and 9.9 nM, respectively..For the detailed information of APY-0201, the solubility of APY-0201 in water, the solubility of APY-0201 in DMSO, the solubility of APY-0201 in PBS buffer, the animal experiment (test) of APY-0201, the cell expriment (test) of APY-0201, the in vivo, in vitro and clinical trial test of APY-0201, the EC50, IC50,and affinity,of APY-0201
APY0201

Synonyms: CAS NO: 1232221-74-7Molecular Formula: C23H23N7OMolecular Weight: 413.2Purity: 98% minSolubility: in DMSOStorage: -20oC


1508250-71-2 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18501494