amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.

June 21, 2017

prudect name : amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.
AM555S,TAC-101,Amsilarotene

Synonyms: CAS NO: 125973-56-0Molecular Formula: C₂₀H₂₇NO₃Si₂Molecular Weight: 385.60428 Purity: 98% minSolubility: In DMSOStorage: -20°C

1095173-27-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498432