AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.

June 21, 2017

prudect name : AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.
AGI-6780

Synonyms: CAS NO: 1432660-47-3Molecular Formula: C₂₁H₁₈F₃N₃O₃S₂Molecular Weight: 481.51113Purity: 98% minSolubility: in DMSOStorage: -20oC

656247-17-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1849724