Overexpression of the prosurvival Bcl-2 family members (Bcl-2,Bcl-xL,and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. Binding affinities were determined with competitive fluorescence polarization assays and a time-resolved fluorescence resonance energy transfer assay (Ki¡¯s of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). The oral bioavailability of ABT-263 (Navitoclax) in preclinical animal models is 20% to 50%, depending on formulation.

June 21, 2017

prudect name : Overexpression of the prosurvival Bcl-2 family members (Bcl-2,Bcl-xL,and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. Binding affinities were determined with competitive fluorescence polarization assays and a time-resolved fluorescence resonance energy transfer assay (Ki¡¯s of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). The oral bioavailability of ABT-263 (Navitoclax) in preclinical animal models is 20% to 50%, depending on formulation.
ABT-263 (Navitoclax)

Synonyms: ABT-263 (Navitoclax)CAS NO: 923564-51-6Molecular Formula: C₄₇H₅₅ClF₃N₅O₆S₃Molecular Weight: 974.61Purity: 98% minSolubility: In DMSOStorage: −20°C

396091-73-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499723