A66 is a highly specific and selective p110¦Á inhibitor with IC50 of 32,30 and 43 nM for p110¦Á, p110¦Á/E545K, p110¦Á/H1047R, respectively. A66 S potently blocks phosphorylation of Akt/PKB in a subgroup of the cell lines tested demonstrates that some cell types are highly dependent on p110¦Á activity. A66 is more than 100 fold less active against the other class-I PI 3-kinase isoforms and had not inhibitory activity against 200 protein kinases when tested at 10 micromolar. This makes it the most selective and specific p110alpha inhibitor available for research purposes. A66 S is more efficacious at inducing growth delay in HCT116. While A66 S did not induce tumor regression in xenograft models the ability to induce growth delay indicates p110¦Á selective have to ability to be effective as cytostatic agents in some tumor types.

June 21, 2017

prudect name : A66 is a highly specific and selective p110¦Á inhibitor with IC50 of 32,30 and 43 nM for p110¦Á, p110¦Á/E545K, p110¦Á/H1047R, respectively. A66 S potently blocks phosphorylation of Akt/PKB in a subgroup of the cell lines tested demonstrates that some cell types are highly dependent on p110¦Á activity. A66 is more than 100 fold less active against the other class-I PI 3-kinase isoforms and had not inhibitory activity against 200 protein kinases when tested at 10 micromolar. This makes it the most selective and specific p110alpha inhibitor available for research purposes. A66 S is more efficacious at inducing growth delay in HCT116. While A66 S did not induce tumor regression in xenograft models the ability to induce growth delay indicates p110¦Á selective have to ability to be effective as cytostatic agents in some tumor types.
A66

Synonyms: CAS NO: 1166227-08-2Molecular Formula: C₁₇H₂₃N₅O₂S₂Molecular Weight: 393.53Purity: 98% minSolubility: In DMSOStorage: -20°C

208255-80-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499772