17-phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.1¨J,2¨J 17-phenyl trinor PGE2 causes contraction of the guinea pig ileum at a concentration of 11 µM.1¨J It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.2¨J With an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.2¨J 1 Lawrence, R.A., Jones, R.L., Wilson, N.H.. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br J Pharmacol 105 271-278 (1992). 2 Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9 9-18 (1975).

June 21, 2017

prudect name : 17-phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.1¨J,2¨J 17-phenyl trinor PGE2 causes contraction of the guinea pig ileum at a concentration of 11 µM.1¨J It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.2¨J With an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.2¨J
1 Lawrence, R.A., Jones, R.L., Wilson, N.H.. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br J Pharmacol 105 271-278 (1992).

2 Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9 9-18 (1975).
17-phenyl trinor PGE2

Synonyms: CAS NO: 38315-43-4Molecular Formula: C23H30O5Molecular Weight: 386.5Purity: 99%Solubility: Storage: −20°C


PF-04691502 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18489269